Özet

Rejeneratif diş hekimliği kök hücre, biyoaktif moleküller ve iskelelerin birleşiminden oluşan ve hızla gelişen rejeneratif tıbbın bir dalıdır. Kök hücreler; kendilerini yenileyebilme, başka hücrelere dönüşebilme, sınırsız çoğalabilme ve hasarlı dokuyu onarabilme özellikleri bulunan, vücudumuzdaki bütün doku ve organları oluşturan hücreler olarak tanımlanabilir.

Klinikte en çok çalışılan erişkin kök hücre türleri hematopoetik ve mezenkimal kök hücrelerdir. Mezenkimal kök hücreler (MSC), bağ dokunun ana hücreleridir ve tüm dokularda destek hücreleri olan stromal hücrelerinde kökenini oluşturmaktadırlar. Diş kaynaklı kök hücreler rejeneratif tıp alanında yapılan çalışmalarda önemli kullanım alanına sahiptir. Diş hekimliğinde kök hücreler, alveolar kemik, dentin-pulpa kompleksi, periodonsium ve ağız boşluğu ile ilişkili diğer yumuşak dokuların rejenerasyonunu sağlamak için kullanılmaya başlanmış ve çalışmalar hız kazanmıştır.

Rejeneratif diş hekimliğinde mevcut araştırmalar, doku rejenerasyonuna aracılık edecek biyomateryaller, biyoaktif maleküller ve MSC kombinasyonu ile ilerlemektedir.

Anahtar Kelimeler

Kök Hücre, Rejeneratif Tıp, Doku Mühendisliği, Biyomalzemeler

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Abstract

Regenerative dentistry is a rapidly developing branch of regenerative medicine that combines stem cells, bioactive molecules and scaffolds. Stem cells can be defined as the cells that make up all the tissues and organs in our body, which have the ability to renew themselves, transform into other cells, multiply indefinitely and repair damaged tissue.

The most widely studied adult stem cell types in the clinic are haematopoietic and mesenchymal stem cells. Mesenchymal stem cells (MSCs) are the major cells of connective tissue and give rise to stromal cells, the supporting cells in all tissues. Tooth-derived stem cells have an important application in regenerative medicine. In dentistry, stem cells have been used to regenerate alveolar bone, the dentin-pulp complex, the periodontium and other soft tissues associated with the oral cavity.

Current research in regenerative dentistry is advancing the combination of biomaterials, bioactive molecules and MSCs to mediate tissue regeneration.

Keywords

Stem Cells, Regenerative Medicine, Tissue Engineering, Biomaterials

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